Is the mattress protector hypoallergenic? April 13, 2022 19:31 Updated Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Is there anything I can do to help prolong the life of my mattress? Can I adjust the firmness of the premium shredded foam pillow? Will the mattress protector reduce breathability of the mattress? Is the mattress protector a full encasement? How are your mattresses shipped?