Is the mattress protector hypoallergenic? April 13, 2022 19:31 Updated Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Is the mattress protector a full encasement? Will the mattress protector reduce breathability of the mattress? How do you ship your products? How do I set up my mattress? Do I need a mattress protector?