Is the mattress protector hypoallergenic? April 13, 2022 19:31 Updated Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Are your products certified safe and healthy? Will the mattress protector reduce breathability of the mattress? What material is the mask made from? Is the mattress protector a full encasement? Do I need a box foundation for your mattress?